Design and Characterization of Cholesterylated Peptide HIV-1/2 Fusion Inhibitors with Extremely Potent and Long-Lasting Antiviral Activity

HIV infection requires lifelong treatment with multiple antiretroviral drugs in a combination, which ultimately causes cumulative toxicities and drug resistance, thus necessitating the development of novel antiviral agents. We recently found that enfuvirtide (T-20)-based lipopeptides conjugated with...

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Vydáno v:J Virol
Hlavní autoři: Zhu, Yuanmei, Chong, Huihui, Yu, Danwei, Guo, Yan, Zhou, Yusen, He, Yuxian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532087/
https://ncbi.nlm.nih.gov/pubmed/30867304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02312-18
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