Modulation of Sialic Acid Dependence Influences the Central Nervous System Transduction Profile of Adeno-associated Viruses

Central nervous system (CNS) transduction by systemically administered recombinant adeno-associated viral (AAV) vectors requires crossing the blood-brain barrier (BBB). We recently mapped a structural footprint on the AAVrh.10 capsid, which, when grafted onto the AAV1 capsid (AAV1RX), enables viral...

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Foilsithe in:J Virol
Main Authors: Albright, Blake H., Simon, Katherine E., Pillai, Minakshi, Devlin, Garth W., Asokan, Aravind
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2019
Ábhair:
Virus-Cell Interactions
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532073/
https://ncbi.nlm.nih.gov/pubmed/30894463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00332-19
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