Conformational Engineering of HIV-1 Env Based on Mutational Tolerance in the CD4 and PG16 Bound States

HIV-1 infection is initiated by viral Env engaging the host receptor CD4, triggering Env to transition from a “closed” to “open” conformation during the early events of virus-cell membrane fusion. To understand how Env sequence accommodates this conformational change, mutational landscapes decoupled...

Full description

Saved in:
Bibliographic Details
Published in:J Virol
Main Authors: Heredia, Jeremiah D., Park, Jihye, Choi, Hannah, Gill, Kevin S., Procko, Erik
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532070/
https://ncbi.nlm.nih.gov/pubmed/30894475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00219-19
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items