LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

Progressive aggregation of the protein alpha-synuclein (α-syn) and loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) are key histopathological hallmarks of Parkinson’s disease (PD). Accruing evidence suggests that α-syn pathology can propagate through neuronal circuits in the...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol
Main Authors: Bieri, Gregor, Brahic, Michel, Bousset, Luc, Couthouis, Julien, Kramer, Nicholas J., Ma, Rosanna, Nakayama, Lisa, Monbureau, Marie, Defensor, Erwin, Schüle, Birgitt, Shamloo, Mehrdad, Melki, Ronald, Gitler, Aaron D.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2019
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531417/
https://ncbi.nlm.nih.gov/pubmed/30927072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-01995-0
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