A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer

Colorectal cancer remains a leading source of cancer mortality worldwide. Initial response is often followed by emergent resistance that is poorly responsive to targeted therapies, reflecting currently undruggable cancer drivers such as KRAS and overall genomic complexity. Here, we report a novel ap...

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Foilsithe in:Sci Adv
Main Authors: Bangi, Erdem, Ang, Celina, Smibert, Peter, Uzilov, Andrew V., Teague, Alexander G., Antipin, Yevgeniy, Chen, Rong, Hecht, Chana, Gruszczynski, Nelson, Yon, Wesley J., Malyshev, Denis, Laspina, Denise, Selkridge, Isaiah, Rainey, Hope, Moe, Aye S., Lau, Chun Yee, Taik, Patricia, Wilck, Eric, Bhardwaj, Aarti, Sung, Max, Kim, Sara, Yum, Kendra, Sebra, Robert, Donovan, Michael, Misiukiewicz, Krzysztof, Schadt, Eric E., Posner, Marshall R., Cagan, Ross L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Association for the Advancement of Science 2019
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531007/
https://ncbi.nlm.nih.gov/pubmed/31131321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav6528
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