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Drosophila Lung Cancer Models Identify Trametinib Plus Statin as Candidate Therapeutic
We have developed a Drosophila lung cancer model by targeting Ras1(G12V)—alone or in combination with PTEN knockdown—to the Drosophila tracheal system. This led to overproliferation of tracheal tissue, formation of tumor-like growths, and animal lethality. Screening a library of FDA approved drugs i...
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| Publicado no: | Cell Rep |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4904304/ https://ncbi.nlm.nih.gov/pubmed/26832408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.105 |
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