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Impact of a patient-derived hepatitis C viral RNA genome with a mutated microRNA binding site
Hepatitis C virus (HCV) depends on liver-specific microRNA miR-122 for efficient viral RNA amplification in liver cells. This microRNA interacts with two different conserved sites at the very 5’ end of the viral RNA, enhancing miR-122 stability and promoting replication of the viral RNA. Treatment o...
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| Publicat a: | PLoS Pathog |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6530871/ https://ncbi.nlm.nih.gov/pubmed/31075158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007467 |
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