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Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production

MicroRNAs (miRNAs) are noncoding RNAs with important roles in regulating gene expression. In studying the earliest nuclear steps of miRNA biogenesis, we observe that primary miRNA (pri-miRNA) transcripts retained at transcription sites due to the deletion of 3′-end processing signals are converted m...

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Bibliografski detalji
Glavni autori: Pawlicki, Jan M., Steitz, Joan A.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447899/
https://ncbi.nlm.nih.gov/pubmed/18625843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200803111
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