Primary microRNA transcripts are processed co-transcriptionally

microRNAs (miRNAs) are generated from long primary (pri-) RNA polymerase II (Pol II)–derived transcripts by two RNase III processing reactions: Drosha cleavage of nuclear pri-miRNAs and Dicer cleavage of cytoplasmic pre-miRNAs. Here we show that Drosha cleavage occurs during transcription acting on...

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Vydáno v:Nat Struct Mol Biol
Hlavní autoři: Morlando, Mariangela, Ballarino, Monica, Gromak, Natalia, Pagano, Francesca, Bozzoni, Irene, Proudfoot, Nick J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952270/
https://ncbi.nlm.nih.gov/pubmed/19172742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1475
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