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Double Knockout of Akt2 and AMPK Predisposes Cardiac Aging without Affecting Lifespan: Role of Autophagy and Mitophagy
Increased age often leads to a gradual deterioration in cardiac geometry and contractile function although the precise mechanism remains elusive. Both Akt and AMPK play an essential role in the maintenance of cardiac homeostasis. This study examined the impact of ablation of Akt2 (the main cardiac i...
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| Publicado no: | Biochim Biophys Acta Mol Basis Dis |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6530587/ https://ncbi.nlm.nih.gov/pubmed/31109453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2018.08.011 |
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