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Localization of ligands within human carbonic anhydrase II using (19)F pseudocontact shift analysis
Unraveling the native structure of protein–ligand complexes in solution enables rational drug design. We report here the use of (19)F pseudocontact shift (PCS) NMR as a method to determine fluorine positions of high affinity ligands bound within the drug target human carbonic anhydrase II with high...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6530540/ https://ncbi.nlm.nih.gov/pubmed/31183057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc05683h |
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