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Localization of ligands within human carbonic anhydrase II using (19)F pseudocontact shift analysis
Unraveling the native structure of protein–ligand complexes in solution enables rational drug design. We report here the use of (19)F pseudocontact shift (PCS) NMR as a method to determine fluorine positions of high affinity ligands bound within the drug target human carbonic anhydrase II with high...
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| Yayımlandı: | Chem Sci |
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| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Royal Society of Chemistry
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6530540/ https://ncbi.nlm.nih.gov/pubmed/31183057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc05683h |
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