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Localization of ligands within human carbonic anhydrase II using (19)F pseudocontact shift analysis
Unraveling the native structure of protein–ligand complexes in solution enables rational drug design. We report here the use of (19)F pseudocontact shift (PCS) NMR as a method to determine fluorine positions of high affinity ligands bound within the drug target human carbonic anhydrase II with high...
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| Publicado en: | Chem Sci |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6530540/ https://ncbi.nlm.nih.gov/pubmed/31183057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc05683h |
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