SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response

Binding of antigen to IgE-high affinity FcεRI complexes on mast cells and basophils results in the release of preformed mediators such as histamine and de novo synthesis of cytokines causing allergic reactions. Src-like adapter protein (SLAP) functions co-operatively with c-Cbl to negatively regulat...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Sharma, Namit, Ponce, Marta, Kaul, Savar, Pan, Zhongda, Berry, Donna M., Eiwegger, Thomas, McGlade, Catherine J.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529641/
https://ncbi.nlm.nih.gov/pubmed/31156621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01020
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