Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment

Proapoptotic tumor suppressor WWOX is upregulated in the early stage of cancer initiation, which probably provides limitation to cancer growth and progression. Later, WWOX protein is reduced to enhance cancer cell growth, migration, invasiveness and metastasis. To understand how WWOX works in contro...

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Udgivet i:Cell Death Discov
Main Authors: Chou, Pei-Yi, Lai, Feng-Jie, Chen, Yu-An, Sie, Yong-Da, Kuo, Hsiang-Ling, Su, Wan-Pei, Wu, Chia-Yun, Liu, Tsung-Yun, Wen, Kuang-Yu, Hsu, Li-Jin, Sze, Chun-I, Chang, Nan-Shan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529460/
https://ncbi.nlm.nih.gov/pubmed/31123603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-019-0176-4
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