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Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031
Gemcitabine is a fluoropyrimidine analogue that is used as a mainstay of chemotherapy treatment for pancreatic and ovarian cancers, amongst others. Despite its widespread use, gemcitabine achieves responses in less than 10% of patients with metastatic pancreatic cancer and has a very limited impact...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6529431/ https://ncbi.nlm.nih.gov/pubmed/31113993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44089-3 |
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