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The α2,3-selective potentiator of GABA(A) receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats
Clinical evidence indicates that positive allosteric modulators (PAMs) of GABA(A) receptors have analgesic benefit in addition to efficacy in anxiety disorders. However, the utility of GABA(A) receptor PAMs as analgesics is compromised by the central nervous system side effects of non-selective pote...
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| 出版年: | Pharmacol Biochem Behav |
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6529285/ https://ncbi.nlm.nih.gov/pubmed/30825491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2019.02.013 |
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