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The α2,3-selective potentiator of GABA(A) receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

Clinical evidence indicates that positive allosteric modulators (PAMs) of GABA(A) receptors have analgesic benefit in addition to efficacy in anxiety disorders. However, the utility of GABA(A) receptor PAMs as analgesics is compromised by the central nervous system side effects of non-selective pote...

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書誌詳細
出版年:Pharmacol Biochem Behav
主要な著者: Witkin, J. M., Cerne, R., Davis, P. G., Freeman, K. B., do Carmo, J. M., Rowlett, J. K., Methuku, K. R., Okun, A., Gleason, S. D., Li, X., Krambis, M. J., Poe, M., Li, G., Schkeryantz, J. M., Jahan, R., Yang, L., Guo, W., Golani, L. K., Anderson, W. H., Catlow, J. T., Jones, T. M., Porreca, F., Smith, J. L., Knopp, K. L., Cook, J. M.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529285/
https://ncbi.nlm.nih.gov/pubmed/30825491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2019.02.013
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