The α2,3-selective potentiator of GABA(A) receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

Clinical evidence indicates that positive allosteric modulators (PAMs) of GABA(A) receptors have analgesic benefit in addition to efficacy in anxiety disorders. However, the utility of GABA(A) receptor PAMs as analgesics is compromised by the central nervous system side effects of non-selective pote...

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Publicat a:Pharmacol Biochem Behav
Autors principals: Witkin, J. M., Cerne, R., Davis, P. G., Freeman, K. B., do Carmo, J. M., Rowlett, J. K., Methuku, K. R., Okun, A., Gleason, S. D., Li, X., Krambis, M. J., Poe, M., Li, G., Schkeryantz, J. M., Jahan, R., Yang, L., Guo, W., Golani, L. K., Anderson, W. H., Catlow, J. T., Jones, T. M., Porreca, F., Smith, J. L., Knopp, K. L., Cook, J. M.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529285/
https://ncbi.nlm.nih.gov/pubmed/30825491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2019.02.013
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