Roflumilast enhances cisplatin‐sensitivity and reverses cisplatin‐resistance of ovarian cancer cells via cAMP/PKA/CREB‐FtMt signalling axis

OBJECTIVE: We previously demonstrated the roflumilast inhibited cell proliferation and increased cell apoptosis in ovarian cancer. In this study, we aimed to investigate the roles of roflumilast in development of cisplatin (DDP)‐sensitive and ‐resistant ovarian cancer. METHODS: OVCAR3 and SKOV3 were...

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Bibliografiske detaljer
Udgivet i:Cell Prolif
Main Authors: Gong, Shipeng, Chen, Yongning, Meng, Fanliang, Zhang, Yadi, Li, Chanyuan, Zhang, Guangping, Huan, Wu, Wu, Fei
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528923/
https://ncbi.nlm.nih.gov/pubmed/30069985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12474
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