Roflumilast enhances cisplatin‐sensitivity and reverses cisplatin‐resistance of ovarian cancer cells via cAMP/PKA/CREB‐FtMt signalling axis

OBJECTIVE: We previously demonstrated the roflumilast inhibited cell proliferation and increased cell apoptosis in ovarian cancer. In this study, we aimed to investigate the roles of roflumilast in development of cisplatin (DDP)‐sensitive and ‐resistant ovarian cancer. METHODS: OVCAR3 and SKOV3 were...

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Vydáno v:Cell Prolif
Hlavní autoři: Gong, Shipeng, Chen, Yongning, Meng, Fanliang, Zhang, Yadi, Li, Chanyuan, Zhang, Guangping, Huan, Wu, Wu, Fei
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528923/
https://ncbi.nlm.nih.gov/pubmed/30069985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12474
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