Roflumilast enhances cisplatin‐sensitivity and reverses cisplatin‐resistance of ovarian cancer cells via cAMP/PKA/CREB‐FtMt signalling axis

OBJECTIVE: We previously demonstrated the roflumilast inhibited cell proliferation and increased cell apoptosis in ovarian cancer. In this study, we aimed to investigate the roles of roflumilast in development of cisplatin (DDP)‐sensitive and ‐resistant ovarian cancer. METHODS: OVCAR3 and SKOV3 were...

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Detaylı Bibliyografya
Yayımlandı:Cell Prolif
Asıl Yazarlar: Gong, Shipeng, Chen, Yongning, Meng, Fanliang, Zhang, Yadi, Li, Chanyuan, Zhang, Guangping, Huan, Wu, Wu, Fei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528923/
https://ncbi.nlm.nih.gov/pubmed/30069985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12474
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