Human Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Breast Cancer Patients

BACKGROUND: Molecular targeted chemotherapies have been shown to significantly improve cancer patient outcomes, but often cause cardiovascular side effects that limit their use and impair patients’ quality of life. Cardiac dysfunction induced by these therapies, especially trastuzumab, shows a disti...

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Bibliographic Details
Published in:Circulation
Main Authors: Kitani, Tomoya, Ong, Sang-Ging, Lam, Chi Keung, Rhee, June-Wha, Zhang, Joe Z., Oikonomopoulos, Angelos, Ma, Ning, Tian, Lei, Lee, Jaecheol, Telli, Melinda L., Witteles, Ronald M., Sharma, Arun, Sayed, Nazish, Wu, Joseph C.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528817/
https://ncbi.nlm.nih.gov/pubmed/30866650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.037357
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