Human Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Breast Cancer Patients

BACKGROUND: Molecular targeted chemotherapies have been shown to significantly improve cancer patient outcomes, but often cause cardiovascular side effects that limit their use and impair patients’ quality of life. Cardiac dysfunction induced by these therapies, especially trastuzumab, shows a disti...

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Publicado en:Circulation
Autores principales: Kitani, Tomoya, Ong, Sang-Ging, Lam, Chi Keung, Rhee, June-Wha, Zhang, Joe Z., Oikonomopoulos, Angelos, Ma, Ning, Tian, Lei, Lee, Jaecheol, Telli, Melinda L., Witteles, Ronald M., Sharma, Arun, Sayed, Nazish, Wu, Joseph C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528817/
https://ncbi.nlm.nih.gov/pubmed/30866650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.037357
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