Human Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Breast Cancer Patients

BACKGROUND: Molecular targeted chemotherapies have been shown to significantly improve cancer patient outcomes, but often cause cardiovascular side effects that limit their use and impair patients’ quality of life. Cardiac dysfunction induced by these therapies, especially trastuzumab, shows a disti...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Kitani, Tomoya, Ong, Sang-Ging, Lam, Chi Keung, Rhee, June-Wha, Zhang, Joe Z., Oikonomopoulos, Angelos, Ma, Ning, Tian, Lei, Lee, Jaecheol, Telli, Melinda L., Witteles, Ronald M., Sharma, Arun, Sayed, Nazish, Wu, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528817/
https://ncbi.nlm.nih.gov/pubmed/30866650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.037357
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