Targeting the BRD4-HOXB13 Co-regulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer

Resistance to Androgen receptor (AR) antagonists is a significant problem in the treatment of Castration resistant prostate cancers (CRPCs). Identification of the mechanisms by which CRPCs evade Androgen Deprivation Therapies (ADT) is critical to develop novel therapeutics. We uncovered that CRPCs r...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Mol Cancer Ther
मुख्य लेखकों: Nerlakanti, Niveditha, Yao, Jiqiang, Nguyen, Duy T., Patel, Ami K., Eroshkin, Alexey M., Lawrence, Harshani R., Ayaz, Muhammad, Kuenzi, Brent M., Agarwal, Neha, Chen, Yunyun, Gunawan, Steven, Karim, Rezaul M., Berndt, Norbert, Puskas, John, Magliocco, Anthony M., Coppola, Domenico, Dhillon, Jasreman, Zhang, Jingsong, Shymalagovindarajan, Subramaniam, Rix, Uwe, Kim, Youngchul, Perera, Ranjan, Lawrence, Nicholas J., Schonbrunn, Ernst, Mahajan, Kiran
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2018
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528782/
https://ncbi.nlm.nih.gov/pubmed/30242092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0602
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