Targeting the BRD4-HOXB13 Co-regulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer

Resistance to Androgen receptor (AR) antagonists is a significant problem in the treatment of Castration resistant prostate cancers (CRPCs). Identification of the mechanisms by which CRPCs evade Androgen Deprivation Therapies (ADT) is critical to develop novel therapeutics. We uncovered that CRPCs r...

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Publicado no:Mol Cancer Ther
Main Authors: Nerlakanti, Niveditha, Yao, Jiqiang, Nguyen, Duy T., Patel, Ami K., Eroshkin, Alexey M., Lawrence, Harshani R., Ayaz, Muhammad, Kuenzi, Brent M., Agarwal, Neha, Chen, Yunyun, Gunawan, Steven, Karim, Rezaul M., Berndt, Norbert, Puskas, John, Magliocco, Anthony M., Coppola, Domenico, Dhillon, Jasreman, Zhang, Jingsong, Shymalagovindarajan, Subramaniam, Rix, Uwe, Kim, Youngchul, Perera, Ranjan, Lawrence, Nicholas J., Schonbrunn, Ernst, Mahajan, Kiran
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528782/
https://ncbi.nlm.nih.gov/pubmed/30242092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0602
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