MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-enhancers at Tumor Suppressor Genes

Super-enhancers are clusters of enhancers, which activate gene expression. Broad trimethyl histone H3 lysine 4 (H3K4me3) often defines active tumor suppressor genes. However, how these epigenomic signatures are regulated for tumor suppression is little understood. Here, we show that brain-specific k...

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Publicado no:Mol Cell
Main Authors: Dhar, Shilpa S., Zhao, Dongyu, Lin, Tao, Gu, Bingnan, Pal, Khusboo, Wu, Sarah J., Alam, Hunain, Lv, Jie, Yun, Kyuson, Gopalakrishnan, Vidya, Flores, Elsa R., Northcott, Paul A., Rajaram, Veena, Li, Wei, Shilatifard, Ali, Sillitoe, Roy V., Chen, Kaifu, Lee, Min Gyu
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528658/
https://ncbi.nlm.nih.gov/pubmed/29861161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.04.028
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