MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-enhancers at Tumor Suppressor Genes

Super-enhancers are clusters of enhancers, which activate gene expression. Broad trimethyl histone H3 lysine 4 (H3K4me3) often defines active tumor suppressor genes. However, how these epigenomic signatures are regulated for tumor suppression is little understood. Here, we show that brain-specific k...

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Publicat a:Mol Cell
Autors principals: Dhar, Shilpa S., Zhao, Dongyu, Lin, Tao, Gu, Bingnan, Pal, Khusboo, Wu, Sarah J., Alam, Hunain, Lv, Jie, Yun, Kyuson, Gopalakrishnan, Vidya, Flores, Elsa R., Northcott, Paul A., Rajaram, Veena, Li, Wei, Shilatifard, Ali, Sillitoe, Roy V., Chen, Kaifu, Lee, Min Gyu
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528658/
https://ncbi.nlm.nih.gov/pubmed/29861161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.04.028
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