Biocatalytic Detoxification of Paralytic Shellfish Toxins

[Image: see text] Small molecules that bind to voltage-gated sodium channels (VGSCs) are promising leads in the treatment of numerous neurodegenerative diseases and pain. Nature is a highly skilled medicinal chemist in this regard, designing potent VGSC ligands capable of binding to and blocking the...

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Bibliografske podrobnosti
izdano v:ACS Chem Biol
Main Authors: Lukowski, April L., Denomme, Nicholas, Hinze, Meagan E., Hall, Sherwood, Isom, Lori L., Narayan, Alison R. H.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2019
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528162/
https://ncbi.nlm.nih.gov/pubmed/30983320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00123
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