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Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins

There is still no successful strategy to treat Huntington’s disease, an inherited autosomal disorder associated with the aggregation of mutated forms of the huntingtin protein containing polyglutamine tracts with more than 36 repeats. Recent experimental evidence is challenging the conventional view...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Bonfanti, Silvia, Lionetti, Maria Chiara, Fumagalli, Maria Rita, Chirasani, Venkat R., Tiana, Guido, Dokholyan, Nikolay V., Zapperi, Stefano, La Porta, Caterina A. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527588/
https://ncbi.nlm.nih.gov/pubmed/31110208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44151-0
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