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Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins

There is still no successful strategy to treat Huntington’s disease, an inherited autosomal disorder associated with the aggregation of mutated forms of the huntingtin protein containing polyglutamine tracts with more than 36 repeats. Recent experimental evidence is challenging the conventional view...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Bonfanti, Silvia, Lionetti, Maria Chiara, Fumagalli, Maria Rita, Chirasani, Venkat R., Tiana, Guido, Dokholyan, Nikolay V., Zapperi, Stefano, La Porta, Caterina A. M.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527588/
https://ncbi.nlm.nih.gov/pubmed/31110208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44151-0
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