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Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins

There is still no successful strategy to treat Huntington’s disease, an inherited autosomal disorder associated with the aggregation of mutated forms of the huntingtin protein containing polyglutamine tracts with more than 36 repeats. Recent experimental evidence is challenging the conventional view...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Bonfanti, Silvia, Lionetti, Maria Chiara, Fumagalli, Maria Rita, Chirasani, Venkat R., Tiana, Guido, Dokholyan, Nikolay V., Zapperi, Stefano, La Porta, Caterina A. M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527588/
https://ncbi.nlm.nih.gov/pubmed/31110208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44151-0
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