In vivo Brain GPCR Signaling Elucidated by Phosphoproteomics

Obtaining a systems view of G protein-coupled receptor (GPCR) signaling in its native environment is the key in development of GPCR therapeutics with fewer side effects. Using the kappa opioid receptor (KOR), a model GPCR, we employed high-throughput phosphoproteomics to investigate downstream signa...

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Bibliografiska uppgifter
I publikationen:Science
Huvudupphovsmän: Liu, Jeffrey J., Sharma, Kirti, Zangrandi, Luca, Chen, Chongguang, Humphrey, Sean, Chiu, Yi-Ting, Spetea, Mariana, Liu-Chen, Lee-Yuan, Schwarzer, Christoph, Mann, Matthias
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527112/
https://ncbi.nlm.nih.gov/pubmed/29930108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao4927
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