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In vivo Brain GPCR Signaling Elucidated by Phosphoproteomics
Obtaining a systems view of G protein-coupled receptor (GPCR) signaling in its native environment is the key in development of GPCR therapeutics with fewer side effects. Using the kappa opioid receptor (KOR), a model GPCR, we employed high-throughput phosphoproteomics to investigate downstream signa...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6527112/ https://ncbi.nlm.nih.gov/pubmed/29930108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao4927 |
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