Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1

BECN1/Beclin 1 is a critical protein in the initiation of autophagosome formation. Recent studies have shown that phosphorylation of BECN1 by STK4/MST1 at threonine 108 (T108) within its BH3 domain blocks macroautophagy/autophagy by increasing BECN1 affinity for its negative regulators, the anti-apo...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Lee, Erinna F., Smith, Nicholas A., Soares da Costa, Tatiana P., Meftahi, Nastaran, Yao, Shenggen, Harris, Tiffany J., Tran, Sharon, Pettikiriarachchi, Anne, Perugini, Matthew A., Keizer, David W., Evangelista, Marco, Smith, Brian J., Fairlie, W. Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper - Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526822/
https://ncbi.nlm.nih.gov/pubmed/30626284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1564557
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