TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia

Macroautophagy/autophagy is a lysosome-dependent catabolic process for the turnover of proteins and organelles in eukaryotes. Autophagy plays an important role in immunity and inflammation, as well as metabolism and cell survival. Diverse immune and inflammatory signals induce autophagy in macrophag...

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Vydáno v:Autophagy
Hlavní autoři: Lee, Ji-Won, Nam, Hyeri, Kim, Leah Eunjung, Jeon, Yoonjeong, Min, Hyunjung, Ha, Shinwon, Lee, Younghwan, Kim, Seon-Young, Lee, Sung Joong, Kim, Eun-Kyoung, Yu, Seong-Woon
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526818/
https://ncbi.nlm.nih.gov/pubmed/30523761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1556946
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