Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration

The retinal pigment epithelium (RPE) supports visual processing and photoreceptor homeostasis via energetically demanding cellular functions. Here, we describe the consequences of repressing peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1α), a master regulator of mitochondrial fu...

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Udgivet i:Life Sci Alliance
Main Authors: Rosales, Mariana Aparecida Brunini, Shu, Daisy Y, Iacovelli, Jared, Saint-Geniez, Magali
Format: Artigo
Sprog:Inglês
Udgivet: Life Science Alliance LLC 2019
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526284/
https://ncbi.nlm.nih.gov/pubmed/31101737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800212
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