Eltrombopag Promotes DNA Repair in Human Hematopoietic Stem and Progenitor Cells

A causal link between hematopoietic stem/progenitor cell (HSPC) dysfunction and DNA damage accrual has been proposed. Clinically relevant strategies to maintain genome integrity in these cells are needed. Here we report that eltrombopag, a small molecule agonist of the thrombopoietin (TPO) receptor...

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Bibliographic Details
Published in:Exp Hematol
Main Authors: Guenther, Kacey L., Cheruku, Patali S., Cash, Ayla, Smith, Richard H., Alvarado, Luigi J., Burkett, Sandra, Townsley, Danielle M., Winkler, Thomas, Larochelle, Andre
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526067/
https://ncbi.nlm.nih.gov/pubmed/30986494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2019.03.002
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