Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer

Histologic transformation to small cell neuroendocrine prostate cancer occurs in a subset of patients with advanced prostate cancer as a mechanism of treatment resistance. Rovalpituzumab tesirine (SC16LD6.5) is an antibody-drug conjugate that targets delta-like protein 3 (DLL3) and was initially dev...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Puca, Loredana, Gavyert, Katie, Sailer, Verena, Conteduca, Vincenza, Dardenne, Etienne, Sigouros, Michael, Isse, Kumiko, Kearney, Megan, Vosoughi, Aram, Fernandez, Luisa, Pan, Heng, Motanagh, Samaneh, Hess, Judy, Donoghue, Adam J., Sboner, Andrea, Wang, Yuzhuo, Dittamore, Ryan, Rickman, David, Nanus, David M., Tagawa, Scott T., Elemento, Olivier, Mosquera, Juan Miguel, Saunders, Laura, Beltran, Himisha
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525633/
https://ncbi.nlm.nih.gov/pubmed/30894499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav0891
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