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DNA methylation analysis and editing in single mammalian oocytes

Mammalian oocytes carry specific nongenetic information, including DNA methylation to the next generation, which is important for development and disease. However, evaluation and manipulation of specific methylation for both functional analysis and therapeutic purposes remains challenging. Here, we...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wei, Yanchang, Lang, Jingwen, Zhang, Qian, Yang, Cai-Rong, Zhao, Zhen-Ao, Zhang, Yixin, Du, Yanzhi, Sun, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525536/
https://ncbi.nlm.nih.gov/pubmed/31010926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817703116
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