Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations

About two million new cases of hepatitis C virus (HCV) infections annually underscore the urgent need for a vaccine. However, this effort has proven challenging because HCV evades neutralizing antibodies (NAbs) through molecular features of viral envelope glycoprotein E2, including hypervariable reg...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Prentoe, Jannick, Velázquez-Moctezuma, Rodrigo, Augestad, Elias H., Galli, Andrea, Wang, Richard, Law, Mansun, Alter, Harvey, Bukh, Jens
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525505/
https://ncbi.nlm.nih.gov/pubmed/31040211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1822002116
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