Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modelling

BACKGROUND: Interleukin-6 is a pleiotropic cytokine with high clinical relevance and an important mediator of cellular communication, orchestrating both pro- and anti-inflammatory processes. Interleukin-6-induced signalling is initiated by binding of IL-6 to the IL-6 receptor α and subsequent bindin...

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Bibliografiske detaljer
Udgivet i:Cell Commun Signal
Main Authors: Reeh, Heike, Rudolph, Nadine, Billing, Ulrike, Christen, Henrike, Streif, Stefan, Bullinger, Eric, Schliemann-Bullinger, Monica, Findeisen, Rolf, Schaper, Fred, Huber, Heinrich J., Dittrich, Anna
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525395/
https://ncbi.nlm.nih.gov/pubmed/31101051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0356-0
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