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Disruption of telomerase RNA maturation kinetics precipitates disease
Mutations in RNA processing enzymes are increasingly linked to human disease. Telomerase RNA and related noncoding RNAs require 3’-end-processing steps including oligoadenylation. Germline mutations in poly(A)ribonuclease (PARN) cause accumulation of extended human telomerase RNA (hTR) species and p...
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| 出版年: | Mol Cell |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6525023/ https://ncbi.nlm.nih.gov/pubmed/30930056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.02.033 |
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