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Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation
Biogenesis of the human telomerase RNA (hTR) involves a complex series of posttranscriptional modifications, including hypermethylation of the 5′ mono-methylguanosine cap to a tri-methylguanosine cap (TMG). How the TMG cap affects hTR maturation is unknown. Here, we show that depletion of trimethylg...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7156301/ https://ncbi.nlm.nih.gov/pubmed/32023455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.01.004 |
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