Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation

Biogenesis of the human telomerase RNA (hTR) involves a complex series of posttranscriptional modifications, including hypermethylation of the 5′ mono-methylguanosine cap to a tri-methylguanosine cap (TMG). How the TMG cap affects hTR maturation is unknown. Here, we show that depletion of trimethylg...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Chen, Lu, Roake, Caitlin M., Galati, Alessandra, Bavasso, Francesca, Micheli, Emanuela, Saggio, Isabella, Schoeftner, Stefan, Cacchione, Stefano, Gatti, Maurizio, Artandi, Steven E., Raffa, Grazia D.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156301/
https://ncbi.nlm.nih.gov/pubmed/32023455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.01.004
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