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Molecular Aggregation of Marketed Recombinant FVIII Products: Biochemical Evidence and Functional Effects
Background Recombinant (rec-) coagulation factor VIII concentrates available for hemophilia A (HA) treatment differ in cell line production and structure, which could affect their pharmacodynamics and immunogenicity. Clinical trials showed that previously untreated patients with severe HA present h...
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| Publicado no: | TH Open |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Georg Thieme Verlag KG
2019
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6524925/ https://ncbi.nlm.nih.gov/pubmed/31249992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0039-1688413 |
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