Mining for Oxysterols in Cyp7b1(−/−) Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5

Deficiency in cytochrome P450 (CYP) 7B1, also known as oxysterol 7α-hydroxylase, in humans leads to hereditary spastic paraplegia type 5 (SPG5) and in some cases in infants to liver disease. SPG5 is medically characterized by loss of motor neurons in the corticospinal tract. In an effort to gain a b...

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Dettagli Bibliografici
Pubblicato in:Biomolecules
Autori principali: Meljon, Anna, Crick, Peter J., Yutuc, Eylan, Yau, Joyce L., Seckl, Jonathan R., Theofilopoulos, Spyridon, Arenas, Ernest, Wang, Yuqin, Griffiths, William J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
Soggetti:
Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6523844/
https://ncbi.nlm.nih.gov/pubmed/31013940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9040149
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