Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma

Cytochrome P450 (CYP) 27A1 is a key enzyme in both the acidic and neutral pathways of bile acid biosynthesis accepting cholesterol and ring-hydroxylated sterols as substrates introducing a (25R)26-hydroxy and ultimately a (25R)26-acid group to the sterol side-chain. In human, mutations in the CYP27A...

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Bibliografske podrobnosti
izdano v:Biochim Biophys Acta Mol Cell Biol Lipids
Main Authors: Griffiths, William J., Crick, Peter J., Meljon, Anna, Theofilopoulos, Spyridon, Abdel-Khalik, Jonas, Yutuc, Eylan, Parker, Josie E., Kelly, Diane E., Kelly, Steven L., Arenas, Ernest, Wang, Yuqin
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327153/
https://ncbi.nlm.nih.gov/pubmed/30471425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2018.11.006
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