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The Modulation of Chitosan-DNA Interaction by Concentration and pH in Solution

Chitosan has been widely used to prepare a DNA carrier for highly efficient and non-toxic gene therapy. In the present study, we investigated DNA charge neutralization and compaction by chitosan in solutions of various pH levels by dynamic light scattering (DLS), magnetic tweezers (MT), and atomic f...

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Detalhes bibliográficos
Publicado no:Polymers (Basel)
Main Authors: Ma, Fangqin, Wang, Yanwei, Yang, Guangcan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6523332/
https://ncbi.nlm.nih.gov/pubmed/30970619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/polym11040646
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