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The importance of sialic acid, pH and ion concentration on the interaction of uromodulin and complement factor H
Uromodulin (UMOD) can bind complement factor H (cFH) and inhibit the activation of complement alternative pathway (AP) by enhancing the cofactor activity of cFH on degeneration of C3b. UMOD, an N‐glycans‐rich glycoprotein, is expressed in thick ascending limb of Henle's loop where the epithelia...
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| Publicado no: | J Cell Mol Med |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8093974/ https://ncbi.nlm.nih.gov/pubmed/33788378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.16492 |
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