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The importance of sialic acid, pH and ion concentration on the interaction of uromodulin and complement factor H
Uromodulin (UMOD) can bind complement factor H (cFH) and inhibit the activation of complement alternative pathway (AP) by enhancing the cofactor activity of cFH on degeneration of C3b. UMOD, an N‐glycans‐rich glycoprotein, is expressed in thick ascending limb of Henle's loop where the epithelia...
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| Pubblicato in: | J Cell Mol Med |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8093974/ https://ncbi.nlm.nih.gov/pubmed/33788378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.16492 |
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