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IL-33 and MRGPRX2-Triggered Activation of Human Skin Mast Cells—Elimination of Receptor Expression on Chronic Exposure, but Reinforced Degranulation on Acute Priming

Clinically relevant exocytosis of mast cell (MC) mediators can be triggered by high-affinity IgE receptor (FcεRI)-aggregation (allergic route) or by the so-called pseudo-allergic pathway elicited via MAS-related G protein-coupled receptor-X2 (MRGPRX2). The latter is activated by drugs and endogenous...

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Bibliografiske detaljer
Udgivet i:Cells
Main Authors: Wang, Zhao, Guhl, Sven, Franke, Kristin, Artuc, Metin, Zuberbier, Torsten, Babina, Magda
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6523246/
https://ncbi.nlm.nih.gov/pubmed/30979016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8040341
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