טוען...
A combined in silico and in vitro study on mouse Serpina1a antitrypsin-deficiency mutants
Certain point-mutations in the human SERPINA1-gene can cause severe α1-antitrypsin-deficiency (A1AT-D). Affected individuals can suffer from loss-of-function lung-disease and from gain-of-function liver-disease phenotypes. However, age of onset and severity of clinical appearance is heterogeneous am...
שמור ב:
| הוצא לאור ב: | Sci Rep |
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| Main Authors: | , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group UK
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6522476/ https://ncbi.nlm.nih.gov/pubmed/31097772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44043-3 |
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